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CBD for Pets

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CBD and erectile dysfunction

NEW STUDIES ON CBD OIL AND ERECTILE DYSFUNCTION SHOW PROMISE

  ALEXANDER KHARYTONOV

Everyday there are new uses for CBD oil being discovered, tested, talked about. Intriguing studies about how it may help with various dementias including Alzheimers are exciting. Another booming area is relief for Erectile Dysfunction.


Erectile Dysfunction is an extremely common affliction among men over 50. It is caused by weakened blood flow and tissue damage, and this is usually caused by Dioxins and other chemical toxins in our environment. These our heavy in our food--especially meat.

The toxins are known to cause E.D.  and low sperm count. Recent research has shown that CBD oil can help get rid of these toxins and prevent them from building up in  fat cells. The oil--which has no pyschoactive effects-- also has been proven to positively stimulate proper hormone production. This can help ease sexual dysfunctions such as infertility, impotency, and performance anxiety.

The pure CBD of Swissx--grown in Gstaad, Switzerland, is potentially much better than big pharma solutions with their scary side effects such as the four hour erection--and even death.  It’s important to try just CBD oil--not other marijuana or hemp products--because the THC (which is what gets you high) can reverse the positive effects of the CBD.  Some CBD oils are poorly made and tested and can have high amounts of THC. Swissx is tested extensively in the U.S. and has the lowest THC of any CBD oil because of its patented strains of hemp plants and its unique process of compounding the CBD oil amount from hemp seeds.

Erectile Dsfunction may be helped by CBD oil. As the Marijuana Times says, “ This recent study provides some degree of nascent evidence that cannabis could interfere with CB2 receptors and therefore treat male infertility. This particular property of cannabis could be exploited as a therapeutic strategy for treatment of male infertility.

The role of the endocannabinoid system (ECS) in the regulation of spermatogenesis, sperm functions and sex hormone synthesis is well documented. So, we have several good reasons to believe that the activation of the ECS by phytocannabinoids can potentially treat, or possibly cure, male infertility by modulating the underlying pathological factor(s).”



 
CBD for anxiety relief
 

Anxiety Relief Without The High? New Studies On CBD, A Cannabis Extract

 
 

A sample of cannabidiol (CBD) oil is dropped into water. Supplements containing the marijuana extract are popular and widely sold as remedies for a variety of ailments and aches. But scientific evidence that they work hasn't yet caught up for most applications, researchers say.

Stefan Wermuth/Bloomberg Creative Photos/Getty Images

As more states legalize marijuana, there's growing interest in a cannabis extract — cannabidiol, also known as CBD.

It's marketed as a compound that can help relieve anxiety — and, perhaps, help ease aches and pains, too.

Part of the appeal, at least for people who don't want to get high, is that CBD doesn't have the same mind-altering effects as marijuana, since it does not contain THC, the psychoactive component of the plant.

"My customers are buying CBD [for] stress relief," says Richard Ferry, the retail manager of Home Grown Apothecary in Portland, Ore., where recreational marijuana use is legal under state law, with some restrictions.

Another rationale Ferry's heard from clients about their CBD use: "Their mother-in-law is in town, and they just want to chill out!"

"CBD has gotten a lot of buzz," Ferry says, as he displays an array of CBD products, including capsules and bottles of liquid CBD oil that users dispense under the tongue with a dropper.

By one estimate, the CBD industry has doubled in size over the last two years, and is now worth $200 million. But with this popularity the hype may have gotten ahead of the science.

 

Former Denver Broncos quarterback Jake Plaummer takes a dose of cannabidiol in Colorado in 2016. CBD oil, often dispensed under the tongue with a dropper, has been regulated as a supplement in the U.S., not a medicine. So strength and purity may vary from brand to brand, or even bottle to bottle, scientists say.

Aaron Ontiveroz/Denver Post via Getty Images

"There's a lot of confusion about how it [CBD] works and what it does exactly," Ferry says.

Researchers now are trying to nail down CBD's effects.

"I think there's good evidence to suggest that CBD could be an effective treatment of anxiety and addiction" and other disorders, says Dr. Esther Blessing, a psychiatrist and researcher at New York University. "But we need clinical trials to find out."

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So far, evidence of the substance's anti-anxiety effect comes from animal research and from very small, short-term human studies that suggest CBD exhibits anti-inflammatory and anti-anxiety properties.

 

The Marijuana Business Conference & Expo in Chicago in 2015 displayed oil containing CBD extracted from agricultural hemp. Today CBD oil alone is estimated to be a $200 million industry.

Carla K. Johnson/AP

These preliminary findings piqued Blessing's interest. For instance, she points to a 2011 study of a few dozen people, some of whom had social anxiety disorder, who were asked to speak in front of a large audience. Researchers compared anxiety levels in people after they took CBD, compared to those who got the placebo or nothing at all. (The participants didn't know if they'd been given the drug or the placebo.)

GW Pharmaceuticals makes Epidiolex, a medicine containing pharmaceutical-grade CBD. Last week, a panel of FDA advisers recommended approval of the drug to treat severe seizure disorders in children.

Kathy Young/AP

And what did the scientists find? "People who took CBD reported significantly less anxiety" compared to those who got the placebo, Blessing says. "It's really interesting."

Now, with funding from the National Institutes of Health, Blessing and group of collaborators are about to begin a clinical trial to test whether CBD can help people with post-traumatic stress disorder who also have moderate or severe alcohol use disorder.

During the study, 50 participants with PTSD coexisting with alcohol use disorder will be given either 400 milligrams of CBD daily, or a placebo. The goal is to see if the participants who take CBD end up drinking less and whether this leads to an improvement in PTSD symptoms. The participants will be given a pharmaceutical-grade CBD, which is more reliable in strength and purity than the supplements that are currently available for sale to the public.

Another Phase 2 clinical trial (to test efficacy and side effects) is exploring whether CBD might help prevent relapse in opioid abusers by reducing craving for the drug. The study's led by Yasmin Hurd, a neuroscientist who directs the Addiction Institute at the Mount Sinai School of Medicine.

Hurd has been trying to rally other top scientists to study CBD's effects and potential benefits in the treatment of substance abuse.

It may seem counterintuitive that a component of marijuana could be useful in treating addiction to another drug. But Blessing says using CBD is very different from using marijuana. Though CBD is extracted from cannabis, it does not lead to altered perception and cognition.

"Drugs can be non-psychoactive and still have an effect on the brain," Blessing says. "CBD does have an effect on the brain, but it seems to affect the brain in possibly medicinal ways." 

Results from Blessing study are a few years off. But in the meantime, just last week, a panel of advisors to the Food and Drug Administration recommended approval of the first pharmaceutical grade CBD, called Epidiolex, to treat severe seizure disorders in children. This could open the door to more research to approve its use in other disorders.

Dr. Robert Carson is a pediatric neurologist at Vanderbilt University who has evaluated the effectiveness of CBD supplements in kids with seizures. He says the supplements can be beneficial for these children. However, he says, if the FDA follows its advisory panel's advice and approves a pharmaceutical-grade CBD drug, that would open up a new treatment option by delivering a high-quality, consistent dose of CBD.

"One of the main caveats I tell my patients who use a CBD supplement is that we cannot guarantee what's in it," Carson explains. "We can't guarantee the consistency."

Supplements aren't regulated as strictly as pharmaceuticals, and can vary widely from bottle to bottle or brand to brand.

And there's another issue would-be users face: Though CBD supplements are widely available for sale, a legal murkiness surrounds marijuana extracts. 

Even if you live in a state where marijuana use is legal, the federal Drug Enforcement Administration still classifies the CBD extract as a Schedule 1 substance — the DEA's most restricted category. According to the agency, "Schedule I drugs, substances or chemicals are defined as drugs with no currently accepted medical use and a high potential for abuse."

Proponents of CBD's use in treating medical conditions and ailments hope the findings of studies now underway will help change that thinking about its legal classification — and its potential benefits.

 
The Endocannabinoid System

The Endocannabinoid System [The ECS Finally Explained]

In nearly every health-related topic that we write about here on MarijuanaBreak, we usually end up going into some sort of discussion about the endocannabinoid system, or ECS. After all, it is borderline impossible to try and explain how cannabis offers relief for a particular medical condition, without discussing the ECS at least in part.

However, we typically only mention the system in passing and don’t go into a great deal of detail about it. That’s why we thought it would be relevant to dedicate an entire article to talking about this phenomenal network of compounds and receptors, which has been described as a “central component of the health and healing of every human, and almost every animal.”

As a disclaimer, though, we will go ahead and say that the ECS is far from being fully understood or fully “mapped.” In fact, having only been discovered in the 1990’s, there is still a lot that scientists and physicians need to learn about it in order to have a more complete understanding of how cannabis works in the body, and more importantly, how we might be able to manipulate it to effectively treat almost any medical condition.

First Things First: Do NOT Let People Tell You There Is A Lack of Scientific Backing For Marijuana

Here’s one of the most annoying (yet ultimately go-to) arguments that marijuana opponents pull out when a discussion pops up over whether or not weed is medically viable: They’ll say something along the lines of, “yeah yeah you can say all you want about how effective weed is, but until there’s scientific evidence, you don’t have a point.”

Well, here’s the thing: over the last 20 years and as of 2015 (this was the last time a detailed account of the number of marijuana studies was taken), there had been no less than 20,991 published scientific articles containing the keyword “cannabinoid.” Since then, there have undoubtedly been hundreds (if not thousands) more studies completed, peer-reviewed, and published.

So the next time you’re talking/arguing with someone about the endocannabinoid system or cannabis in general, don’t let them tell you that there’s no scientific evidence on the subject – because that’s simply not true.

What is a Cannabinoid?

To understand the basic properties and functions of the endocannabinoid system, we first have to understand what a “cannabinoid” is.

Basically, cannabinoids are the active chemical compounds in marijuana, which includes all plants classified under the genus Cannabis (i.e. Cannabis indica, Cannabis sativa, and Cannabis ruderalis, which is the industrial hemp plant).

There have actually been over 80 distinct cannabinoids identified across all species of cannabis, but it appears that far and away the two most important ones in terms of the plant’s effects on the human body are THC (tetrahydrocannabinol) and CBD (cannabidiol). Other natural cannabinoids found in marijuana include CBG, CBC, THCA, and THCV, just to name a few.

In any regard, it is these active cannabinoids which are responsible for the profound and far-reaching effects on the human body’s endocannabinoid system, and ultimately, on the range of therapy and relief that it can provide for so many medical conditions.

What is the Endocannabinoid System?

Believe it or not, just like the marijuana plant, humans actually have naturally occurring cannabinoids as well, which are called “endocannabinoids” (the cannabinoids that occur in marijuana plants are called “phytocannabinoids”).

While there are likely many more that have yet to be discovered, it appears that the two primary endocannabinoids in the human body are anandamide and 2-AG (2-arachidonoylglycerol). It’s a bit of a stretch of the imagination, but you might consider these two molecules to be the “human” versions of THC and CBD.

Also, it’s important to understand that these compounds are produced entirely naturally by the human body – each and every one of us has them, regardless of whether we’ve ever smoked weed before or not. (And in fact, it’s believed that endocannabinoids exist in nearly every living organism on earth, from dogs and dolphins to sea squirts and nematodes).

In terms of function, endocannabinoids work by interacting with their corresponding receptors, which are aptly named “endocannabinoid receptors.” It appears that by far the most important of these internal receptors are CB-1 and CB-2, with CB-1 primarily influencing activity on the brain and CB-2 primarily influencing immune system activity and interactions with body tissues and organ systems. Given their presence across nearly every cell and tissue type in the human body, you might imagine that endocannabinoids (and their corresponding receptors) have influential control over every aspect of both the body and mind, which is a truly amazing concept to consider in terms of the potential health benefits of cannabis.

In fact, the endocannabinoid system (which includes the complete network of cannabinoids and receptors in the body) is so prevalent throughout the human body that it has been described as a “bridge between body and mind” that is potentially “the most important physiologic system involved in establishing and maintaining human health.”

Among (many) other locations, endocannabinoids have been found in abundance throughout the brain, organs, connective tissues, glands, and immune cells, and their activity has been documented to regulate such things as cell-to-cell communication, neurogenesis (new cell production), and even the promotion of apoptosis, which is the death of malignant cancer cells and other non-productive cells through “programmed cellular suicide.”

How Does the Endocannabinoid System Work?

As we mentioned, the ECS functions through the interaction of naturally-occurring compounds (like 2-AG and anandamide) and their receptors. However, this is an extremely basic description – the actual physiological pathways of the various cell-to-cell networks are likely to be highly complex, and much more research is certainly needed in order to even come close to understanding the full capacity of this very involved system.

What’s intriguing, however, is the fact that endocannabinoids can accomplish such a wide range of “bodily tasks” while still maintaining the singular objective of homeostasis. In other words, even though the endocannabinoid system performs dozens and dozens of different tasks inside the body, it ultimately has one singular goal: to make sure that every bodily system is functioning healthily, efficiently, and in tune with other systems.

One of the best examples of an ECS function in the body is how it works to heal tissue after an injury. When a specific site becomes damaged (i.e. “injured”), for instance, anandamide and 2-AG (remember these are the body’s main endocannabinoids) are known to decrease the release of “sensitizers” from the site of injury, which thereby prevents excessive nerve cell firing (i.e. minimizes pain) and also prevents immune cells from releasing inflammation-inducing substances. In this particular example, one can see how the ECS influences three entirely separate pathways on three different cell types in order to accomplish the single objective of minimizing pain and repairing the damaged tissue.

Likewise, the ECS has similarly profound impacts on the brain, nervous system, and our general psychological and emotional well-being. For instance it’s known that endocannabinoid pathways can directly influence an individual’s response to external stimuli, which has potentially massive implications in terms of being able to alter human behavioral responses. More clearly put, the ECS and its network of chemical pathways is believed to be able to directly manipulate (and reverse) the neurological actions that lead to mental disorders like anxiety, depression, and even psychosis.

Also, by influencing the production of new cells in the central nervous system, it has been suggested that cannabinoids may be able to directly mediate an individual’s “open-mindedness,” as well as their capacity to re-format patterns of thought and behavior, which is a crucial aspect of being able to adapt to new situations while maintaining a healthy state of mind.

All in all, given the ECS’ seemingly all-encompassing influence over cell-to-cell communication, cell birth, and even cell death, it truly does appear that the system is a veritable “mind-to-body bridge” with the potential to treat any range of health disorders and diseases, whether they be mental or physical.

How Does Marijuana Work With the Endocannabinoid System?

So you might be wondering, “if every human being has their own endocannabinoid system, then why do we even need cannabis?”

Well, consider this: what do you suppose happens when there’s a deficiency of endocannabinoids, and/or the ECS is not functioning properly in the body? If you guessed that any number of things can go wrong (either physically or psychologically), then you’re exactly right. And this is precisely why marijuana – or cannabis in general – is believed to be able to provide relief from a seemingly endless range of medical conditions. If endocannabinoids like 2-AG and anandamide are responsible for maintaining health and homeostasis on every single cellular level, for instance, then it makes perfect sense that marijuana (with its nearly identically-functioning THC and CBD molecules) can act as a “miracle medicine” in the event of an ECS deficiency.

Also, on a bit of a side note this is why the popularity of CBD has taken off like a bottle rocket in recent years. It’s of course no secret that in addition to its health benefits, marijuana also provides a “substantial” mind-altering high, which is undesirable for a large population of people.

CBD on the other hand (which remember is the second-most abundant cannabinoid in marijuana), does not produce any intoxicating effects. It essentially provides all of the health and therapeutic benefits of cannabis, just without the high.

[To learn more about CBD and its therapeutic effects, check out this article].

What is the Endocannabinoid System: Final Thoughts

Well, hopefully your questions (or at least a portion of them) on what the endocannabinoid system is have finally been answered. In short, it is essentially the body’s own “naturally-occurring marijuana system” – able to influence any range of mind/body functions in order to promote health and homeostasis on a complete, whole-body level.

So matter what it is that you might be suffering from – whether it be a psychological condition such as insomnia or anxiety or a physical condition like pain, inflammation, or diabetes, cannabis is likely able to provide safe, effective, and 100% natural relief.

*[Much of the information in this article was taken from Dr. Dustin Sulak’s article on the ECS for NORML, which is the National Organization for the Reform of Marijuana Laws].

Sources:
http://norml.org/library/item/introduction-to-the-endocannabinoid-system
https://www.news-medical.net/health/What-are-Cannabinoids.aspx

 
 
 
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